Let KAYAK do the searching
Based on KAYAK hotel searches, the most popular destination is Mytilene (62% of total searches to Lesbos). The next most popular destinations are Míthymna (19%) and Sigri (15%). Searches for hotels in Skala Eresou (4%) are also popular.
KAYAK users have found double rooms in Lesbos for as cheap as $48 (Mytilene) in the last 3 days. The average price is $164.