Let KAYAK do the searching
Based on KAYAK hotel searches, the most popular destination is New Orleans (63% of total searches to Mississippi River). The next most popular destinations are Memphis (20%) and Minneapolis (9%). Searches for hotels in Bloomington (8%) are also popular.
KAYAK users have found double rooms in Mississippi River for as cheap as $12 (New Orleans) in the last 3 days. The average price is $253.