Let KAYAK do the searching
Based on KAYAK hotel searches, the most popular destination is Matsuyama (55% of total searches to Ehime Prefecture). The next most popular destinations are Imabari (25%) and Uwajima (10%). Searches for hotels in Shikokuchuo (10%) are also popular.
KAYAK users have found double rooms in Ehime Prefecture for as cheap as $83 (Uwajima) in the last 3 days. The average price is $108.