Let KAYAK do the searching
Based on KAYAK hotel searches, the most popular destination is Chicago (81% of total searches to Midwest). The next most popular destinations are Columbus (7%) and Minneapolis (6%). Searches for hotels in Indianapolis (6%) are also popular.
KAYAK users have found double rooms in Midwest for as cheap as $31 (Topeka) in the last 3 days. The average price is $338.