Let KAYAK do the searching
Based on KAYAK hotel searches, the most popular destination is Marsala (33% of total searches to Sicily South Coast). The next most popular destinations are Ragusa (33%) and Sciacca (25%). Searches for hotels in Mazara del Vallo (8%) are also popular.
KAYAK users have found double rooms in Sicily South Coast for as cheap as $66 (Ragusa) in the last 3 days. The average price is $221.