Panama City luxury hotels

Let KAYAK do the searching

Save on your next stay

Search and compare hundreds of travel sites at once for luxury hotels in Panama City

We’re completely free to use – no hidden charges or fees

Most popular luxury hotels in Panama City

Sofitel Legend Casco Viejo - Panama City

Excellent, 478 reviews

#1 out of 29 hotels

$408+

Check-in

Check-out

The Santa Maria, a Luxury Collection Hotel & Golf Resort, Panama City

Excellent, 810 reviews

#2 out of 29 hotels

$315+

Check-in

Check-out

Ramada Plaza Panama Punta Pacifica

Excellent, 3,490 reviews

#3 out of 29 hotels

$147+

Check-in

Check-out

Bristol Panama, a Registry Collection Hotel

Excellent, 1,255 reviews

#4 out of 29 hotels

$253+

Check-in

Check-out

Gran Evenia Panama

Excellent, 757 reviews

#5 out of 29 hotels

$156+

Check-in

Check-out

Riu Plaza Panama

Excellent, 10,048 reviews

#6 out of 29 hotels

$167+

Check-in

Check-out

Marriott Executive Apartments Panama City, Finisterre

Excellent, 223 reviews

#7 out of 29 hotels

$148+

Check-in

Check-out

American Trade Hotel

Excellent, 574 reviews

#8 out of 29 hotels

$290+

Check-in

Check-out

JW Marriott Panama

Excellent, 1,372 reviews

#9 out of 29 hotels

$306+

Check-in

Check-out

Central Hotel Panama Casco Viejo

Excellent, 1,376 reviews

#10 out of 29 hotels

$290+

Check-in

Check-out

Global Hotel Panama

Excellent, 1,861 reviews

#11 out of 29 hotels

$148+

Check-in

Check-out

Novotel Panama City

Excellent, 1,812 reviews

#12 out of 29 hotels

$90+

Check-in

Check-out

Intercontinental Miramar Panama

Excellent, 801 reviews

#13 out of 29 hotels

$226+

Check-in

Check-out

Las Americas Golden Tower Panama

Excellent, 1,578 reviews

#14 out of 29 hotels

$149+

Check-in

Check-out

W Panama

Excellent, 944 reviews

#15 out of 29 hotels

$265+

Check-in

Check-out

The Westin Panama

Excellent, 244 reviews

#16 out of 29 hotels

$298+

Check-in

Check-out

Waldorf Astoria Panama

Excellent, 348 reviews

#17 out of 29 hotels

$283+

Check-in

Check-out

Sheraton Grand Panama

Excellent, 897 reviews

#18 out of 29 hotels

$169+

Check-in

Check-out

Decapolis Hotel Panama City

Excellent, 4,163 reviews

#19 out of 29 hotels

$121+

Check-in

Check-out

Summit Rainforest & Golf Resort

Excellent, 2,062 reviews

#20 out of 29 hotels

$93+

Check-in

Check-out

Sortis Hotel, Spa & Casino, Autograph Collection

Excellent, 461 reviews

#21 out of 29 hotels

$198+

Check-in

Check-out

Megapolis Hotel Panama

Excellent, 1,236 reviews

#22 out of 29 hotels

$176+

Check-in

Check-out

Crowne Plaza Panama

Excellent, 108 reviews

#23 out of 29 hotels

$107+

Check-in

Check-out

Riande Aeropuerto Hotel Casino

Good, 4,442 reviews

#24 out of 29 hotels

$145+

Check-in

Check-out

Dreams Playa Bonita Panama

Good, 1,290 reviews

#25 out of 29 hotels

$302+

Check-in

Check-out

Le Méridien Panama

Good, 248 reviews

#26 out of 29 hotels

$197+

Check-in

Check-out

Gamboa Rainforest Reserve

Good, 1,098 reviews

#27 out of 29 hotels

$162+

Check-in

Check-out

Hospedium Princess Hotel Panamá

Good, 3,218 reviews

#28 out of 29 hotels

$71+

Check-in

Check-out

Cresta Inn

Good, 4,995 reviews

#29 out of 29 hotels

$65+

Check-in

Check-out